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International Journal of Applied Dental Sciences
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ISSN Print: 2394-7489, ISSN Online: 2394-7497
ICV 2016: 75.37

International Journal of Applied Dental Sciences

2014, Vol. 1 Issue 1, Part A

Comparison of immunoexpression of α-SMA in inflamed and non-inflamed odontogenic keratocyst and ameloblastoma

AUTHOR(S): Joshi Priya, Bhosale Satish, Hongal Bhagyalaxmi, Chougule Madhuri, Dudanakar Mahesh
ABSTRACT:Odontogenic cyst and tumors constitute a group of heterogeneous lesions derived from the tooth forming apparatus and odontogenic epithelial remnants. Odontogenic keratocyst and ameloblastoma though benign exhibit a locally aggressive behaviour. The coordination between the parenchymal and stromal cells plays an important role in pathologic phenomenon like tumor invasion and progression. Myofibroblast is one of the non-epithelial stromal factor which has acquired the capacitance of α-smooth muscle actin expression and synthesis of extracellular matrix components and collagen. However the role of myofibroblast is very sparse in these odontogenic lesions. Hence we designed a study to evaluate the role of α-SMA in Odontogenic keratocyst & Ameloblastoma with an aim to assess the frequency and significance of immunohistochemical expression of α-SMA in inflammed & non-inflammed Odontogenic keratocysts & Ameloblastoma. We conclude that more MF’s in the stroma, are associated with more aggressive behaviour of the odontogenic cyst or tumor.
Pages: 05-10  |  702 Views  4 Downloads
How to cite this article:
Joshi Priya, Bhosale Satish, Hongal Bhagyalaxmi, Chougule Madhuri, Dudanakar Mahesh. Comparison of immunoexpression of α-SMA in inflamed and non-inflamed odontogenic keratocyst and ameloblastoma. International Journal of Applied Dental Sciences. 2014; 1(1): 05-10.
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