AUTHOR(S): Sumita Banerjee, Sanjeeta Ngairangbam, T Premlata Devi, Nandini DB, Saikat Mukherjee and Soumya Dutta

ABSTRACT:
Chlorhexidine Gluconate is a broad-spectrum antimicrobial drug that is widely used as mouthwash. Several clinical studies have proved its safety as a mouthwash when used within pharmacological dose limit. However, severe cytotoxic effects on cultured cell line and even in animal trials also have been reported. Considering these findings, the rationality of the continuous use of Chlorhexidine Gluconate mouth wash for longer duration becomes questionable. To evaluate the genotoxicity of Chlorhexidine Gluconate for long term use within pharmacological dose limit by estimation of Micronucleus index in exfoliated human buccal mucosal cells using Acridine Orange under fluorescence microscope. In result no significant difference in the Micronuclei count in the whole population was observed before and after use of the 0.2% Chlorhexidine mouth wash. Micronucleus count was also unaltered in the male and female population before and after use.

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