Materials and methods: 40 bilateral mandibular class II furcation defects in 20 systemically healthy subjects were randomized as test and control sites using split mouth design. Simvastatin collagen graft was placed in the test sites and collagen graft was placed in the control sites. Alkaline phosphatase level in gingival Crevicular fluid was estimated at baseline, 7 and 14 days post operatively. Horizontal probing depth at furcation site and radiographic assessment of bone fill was made using standardized intraoral periapical radiographs with at baseline, 6, 9, 12 and 15 months. The results were analyzed statistically.

Results: A statistically significant (p<0.05) increase in Alkaline phosphatase levels was observed in test sites in comparison to control sites. A decrease in horizontal probing depth both groups over 15 months. The percentage bone area between the test and control over 15 months showed statistically significant differences.

Conclusion: Simvastatin collagen graft and collagen graft both showed improvements in clinical parameters and evidence of bone formation. The results encourage the adjunctive use of Simvastatin collagen graft for predictable regeneration of grade II furcation defects. Alkaline phosphatase levels in gingival crevicular fluid can be used as an early indicator of bone formation along with other parameters.