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International Journal of Applied Dental Sciences
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P-ISSN: 2394-7489, E-ISSN: 2394-7497
ICV 2019: 92.11

2018, Vol. 4 Issue 4, Part A

Human papillomavirus and the risk of oral potentially malignant disorders of betel-quid chewers in samosir island, Indonesia: an integrated epidemiologic and molecular study

AUTHOR(S): Indri Lubis, Ameta Primasari and Sayuti Hasibuan
ABSTRACT:Human Papillomavirus (HPV) is known to be associated with oral cancer and several types of oral potentially malignant disorders. Recent studies have shown that HPV oncogenes act synergistically with a common risk factor of chemical carcinogens in betel-quid chewing, resulting in oral malignant transformation. The aim of the present study was to investigate the association between HPV with the risk of oral potentially malignant disorders of betel-quid chewers. This case-control study was performed on habitual chewers of betel-quid, surrounded the working area of the local government clinic of Ambarita, regency of Samosir province of North Sumatra, Indonesia. As case group, 28 subjects with oral potentially malignant disorders and as control group, 23 subjects without oral potentially malignant disorders, were assigned into study. All HPV DNA samples were collected by swabing over the oral lesions and mucosa, thereafter performed using nested-polymerase chain reaction. Fisher exact test and multiple logistic regression were used to investigate associations between variables. The present study noted a high prevalence of positive HPV, both in case group (96.4%) and control group (82.6%). Positive HPV increased the risk of oral potentially malignant disorders of betel-quid chewers, but the association was not statistically significant (OR= 5.684; p= 0.162). As the conclusion, the present study highlighted a high prevalence of positive HPV on betel quid chewers in Samosir island Indonesia. Larger studies in this population with both evaluation of low risk and high risk HPV types, were recommended to detect HPV types with more valid empirical associations.
Pages: 17-21  |  1318 Views  113 Downloads
How to cite this article:
Indri Lubis, Ameta Primasari, Sayuti Hasibuan. Human papillomavirus and the risk of oral potentially malignant disorders of betel-quid chewers in samosir island, Indonesia: an integrated epidemiologic and molecular study. Int J Appl Dent Sci 2018;4(4):17-21.
International Journal of Applied Dental Sciences

International Journal of Applied Dental Sciences

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International Journal of Applied Dental Sciences