Objective: This study intended to evaluate efficacy of 2% lignocaine with two different dilutions of epinephrine in equal volumes (1ml), used as infiltration anaesthesia in the extraction of mandibular anteriors and premolars. The following parameters were evaluated: onset, depth and duration of anaesthesia, hemostasis during the procedures, and complications, if any.

Methodology: Forty patients underwent extractions of mandibular teeth (anteriors and premolars) using local infiltration anesthesia of 2% lignocaine. 20 patients received 2% lignocaine with 1:80000 adrenaline and another 20 patients received 2% lignocaine with 1:200000 adrenaline.

Results: It was found that there was statically significant difference in the onset of anesthesia and the duration of action of local anesthesia in study group but not in efficacy and depth of anesthesia.

Conclusion: Longer duration of anaesthesia can be achieved with the use of local infiltration 2% lignocaine with 1:80000 dilution of adrenaline when compared with equal volume of 2% lignocaine with 1:200000 dilution of adrenaline. Hence it can be a choice of local anaesthetic in patients who require longer duration of anaesthesia.