Aim: The specific aim of this intervention trial was to test the short-term effects of periodontal therapy on the systemic inflammatory status of medically healthy individuals suffering from severe, generalized periodontitis.

Materials and Methods: 30 subjects suffering from severe periodontitis were recruited and received standard periodontal therapy. Blood samples were collected at baseline and 30 days after treatment and processed for biomarker CRP by high-sensitivity assay.

Results: One month after treatment, SPT resulted in significant reductions in levels of serum CRP.

Conclusion: Analysis of the data indicates that periodontitis causes moderate systemic inflammation in systemically healthy subjects and SPT can result in the reduction of the inflammatory markers.