Aim: To elicit the effect of non surgical periodontal therapy on the levels of systemic inflammatory markers (Fibrinogen and total white blood cell count) in the chronic generalized periodontitis patients.

Materials and Methods: 40 subjects with chronic generalized periodontitis were included in the study. Oral hygiene instructions were given and scaling and root planing was performed in all the recruited subjects. Data was analysed by Paired t-test. A P-value of less than 0.05 was considered statistically significant.

Results: Non surgical periodontal therapy (scaling and root planing) resulted in statistically significant decrease in the levels of inflammatory markers.

Conclusion: Non surgical periodontal therapy resulted in reduction of systemic inflammatory markers Fibrinogen and WBCS in chronic generalized severe periodontitis patients and thus can help to reduce the risk of systemic diseases.