AUTHOR(S): Dr. Kaushal Singh, Dr. Aakash Tripathi, Dr. Sneha Singh and Dr. Nivedita Sharan Sinha

ABSTRACT:Background: Among the cells involved in immune and inflammatory responses in periodontal disease, mast cells have been shown to be capable of generating a large number of biologically active substances. Mast cells are mobile, bone-marrow-derived, granule-containing immune cells that are found in all connective tissue and mucosal environments and in the peripheral and central nervous systems. Mast cells are able to phagocytose, process and present antigens as effectively as macrophages. The present study was undertaken to quantify the mast cells in health and disease, whether they correlate degree of inflammation and clinical features of periodontitis AIM: The aim of this study was to evaluate the distribution, and their relationship with the degree of inflammatory infiltrate in gingiva from patients with periodontal disease. Source: Forty patients (OPD, DEPT. OF Periodontics). 10 each: Aggressive periodontitis, Chronic Periodontitis, gingivitis and healthy mucosa. Materials And Methods:Gingival specimens of 10 chronic cases, 10 aggressive periodontal cases, 10 gingivitis cases for experimental group and 10 healthy cases as control group in routine periodontal flap and crown lengthening procedures. Specimens: stained by toluidine blue for mast cell counting and hematoxyline/eosin to assess inflammation. Inflammation and mast cells were assessed in 40 x magnification. Results: Mast cell counts were found to be higher in aggressive and chronic periodontitis than healthy/gingivitis cases. Conclusion: Mast cell number is directly proportional to inflammation of tissue.

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