Material and Methods: 40 permanent teeth from 40 healthy patient aged 8-18 years with iatrogenic or carious exposed pulps were randomly divided into 4 groups (n=10) depending on the cause of the exposure and pulpotomy agent. In all specimens 1-2 mm of exposed pulp was removed. After hemostasis, exposed pulps were covered using PRF membrane with MTA or MTA only, then all teeth were restored with glass-ionomer cement and composite resin. Clinical and radiographic evaluation was undertaken at (3, 6, and 12) months intervals. The results were analyzed using appropriate statistical tests.

Results: There were differences between studied groups but they were not significant since most of examined teeth showed positive responses to electrical pulp test and dentinal bridge formation.

Conclusion: PRF could improve the prognosis of pulpotomy procedures of mature permanent teeth.