Aim: To evaluate and compare the effect of various additives on the flexural strength of glass ionomer cement.

Materials and Method: 30 samples for evaluation of compressive strength were equally divided into 3 groups: Group 1- Control (Conventional GIC- Non modified), Group 2: GIC Powder modified with 3% TiO2 and Group 3: GIC Powder modified with 10% Nano Hydroxyapatite.

Result: The mean compressive strength value of Group 5 showed statistically significant higher flexural strength among all the groups (177.14 ± 0.81).

Conclusion: The results of the study revealed that glass ionomer cement powder can be modified with nano-hydroxyapatite and nanotitanium to improve its compressive strength.