Materials and Methods: 60 symptomatic single-rooted teeth were treated endodontically with two different preparation techniques. Teeth were randomly assigned to four groups (n=15):

Group1: ProTaper Universal preparation without cold saline, Group 2: Reciproc Blue preparation without cold saline, Group 3: ProTaper Universal preparation with cold saline 20mm for 5-minute, Group 4: Reciproc Blue preparation with cold saline 20mm for 5-minute. All teeth were restored with GIC temporally, Pain levels were assessed by Visual Analogue Scale (VAS) of pain / discomfort questionnaire after 6, 12, 24, and 48 hours and 7 days of canal obturation.

Results: The results showed that there was a significant difference (P<0.05), in all study periods except after 1 week between Groups 1 and 3.

Conclusion

1. Post- endodontic pain represented in the highest values after12 hours of treatment, and reduced to almost finished after 1 week.

2. The intracanal cryotherapy eliminated post-endodontic pain clinically.