Material and Method: In our work, 330 pieces of 3 different hybrid CAD-CAM ceramics were used. The ceramics were divided into 5 subgroups and their surfaces were treated differently. These were set as bonding with hydrofluoric acid, bonding with CoJet, Silane application with hydrofluoric acid, only bonding application, and control group. The shear bond strength was measured with a universal tester, INSTRON. Values from the measurements were analyzed by one-way ANOVA and the Tukey HSD test was used to determine significant differences (p = 0,05).

Results: Bonding values between CAD/CAM hybrid ceramic blocks subjected to the same surface treatment were statistically significant in all HF applied samples. (p<0,05) The highest bonding values were observed in HF + silane samples (52,24 ± 7,4 MPa) in the Vita Enamic group and the lowest bonding values were detected in HF + UQ samples in the Lava Ultimate group. (21, 26 + 4,4MPa)

Conclusion: Application of HF + Silane and HF + Adhesive can contribute to clinical success by increasing the resin cemented joint strength of hybrid CAD/CAM ceramics.