International Journal of Applied Dental Sciences
2014, Vol. 1 Issue 1, Part A
Immunohistochemical localization of basic fibroblast growth factor (bFGF) in oral squamous cell carcinoma (OSCC)
AUTHOR(S): Dr. Kumar Uddipan, Dr. Thakur Pragya, Dr. Rao Nirmala N, Dr. Raghu Radhakrishnan and Dr. Jiji George
Objective: Basic fibroblastic growth factor (bFGF) is a potent angiogenic factor implicated in tumor growth and metastasis. To determine if bFGF is upregulated in Oral Squamous cell carcinoma (OSCC), we measured the level and intensity of expression of bFGF in various grades of oral squamous cell carcinoma specimens as compared to control specimens.
Methods: Oral squamous cell carcinoma of different grades and control tissue specimens were analyzed qualitatively (32 patients, 5 controls). Control specimen consisted of buccal mucosa tissue.
Results: Immunohistochemical analysis revealed that bFGF was strongly associated with OSCC specimens as compared to the control. The control specimens showed mild staining localized to the basal layers of epithelium. The intensity of expression and the number of cells showing bFGF expression increased significantly with increasing degree of morphological differentiation.
Conclusions: Oral squamous cell carcinoma cells express high levels of bFGF and suggest that these growth factors contribute significantly to cancer cell growth.
Pages: 44-49 | 429 Views 7 Downloads
How to cite this article:
Dr. Kumar Uddipan, Dr. Thakur Pragya, Dr. Rao Nirmala N, Dr. Raghu Radhakrishnan, Dr. Jiji George. Immunohistochemical localization of basic fibroblast growth factor (bFGF) in oral squamous cell carcinoma (OSCC). Int J Appl Dent Sci 2014;1(1):44-49.