AUTHOR(S): Dr. Mayank Sharma, Dr. Tarun Gupta, Dr. Neha Garg

ABSTRACT:
Major usage of medicine along with disease burden is much higher in older individuals, in general, compared with younger adults; yet premarketing drug clinical trials have often excluded them even for the drugs that have high utility in this age group. The older population is currently the fastest growing age group in the United States, and this trend is expected to continue for several decades. Herein, we discuss the information gap for older individuals and the need for a better understanding of the effect of aging on drug responses. We also present cases for future directions, urging the implementation of improved clinical trial designs using new and emerging pharmacokinetic and pharmacodynamic methods to allow the provision of evidence-based individualized treatment to this high drug use group.

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