Aim: To evaluate and compare the apical microleakage of calcium hydroxide (Sealapex), Mineral Trioxide Aggregates (MTA Fillapex) and silicone based (Roekoseal) sealers.

Materials and Methods: Extracted human single rooted teeth were taken and decoronated at cemento-enamel junction. The access cavities and biomechanical preparation were performed using endodontic rotary system. The teeth were randomly divided into three groups with n=10; Group I - Guttapercha and Sealapex sealer; Group II - Gutta-percha and MTA Fillapex; Group III- Gutta-percha and Roeko Seal; and negative control group as empty root canal. All the specimens were stored at 37 °C with 100% humidity for one week. All root surfaces except the apical 2mm were covered with two layers of nail varnish and then immersed in an aqueous solution of 2% methylene blue dye for 72 hours. Roots were longitudinally split using a diamond disk. Linear apical dye penetration was measured under Stereomicroscope at 40X magnifcation.

Results: MTA Fillapex group showed maximum apical microleakage followed by Sealapex and Roeko Seal sealer.

Conclusion: The results concluded that Roeko Seal sealer showed minimal dye penetration followed by Sealapex and MTA Fillapex. Thus, concluding that Roeko Seal sealer is better in apical sealing than Sealapex and MTA Fillapex.