International Journal of Applied Dental Sciences
2018, Vol. 4 Issue 1, Part C
Single application of topical doxycycline hyclate in the management of recurrent aphthous stomatitis
AUTHOR(S): Altaf H Chalkoo, Rizwan Hamid and Dr. Zahoor Bhat
Topical application of tetracyclines have been used in recurrent aphthous stomatitis (RAS) patients but there are few studies describing the use of doxycycline. We evaluated the therapeutic efficacy of topical doxycycline hyclate in RAS.
Study design: A single-blinded placebo-controlled trial was performed, dividing 50 RAS subjects into group A and group B with 25 subjects in each group. Patients in group A received topical application of crushed doxycycline hyclate tablet with denture adhesive (Fixon) and few drops of saline solution just once at the first visit. Group B received placebo similarly. Treatment response was assessed by measuring pain reduction, ulcer duration, and adhesive retention time. Data were analyzed using the Student’s t-test.
Results: Participants who received doxycycline hyclate had significantly less pain by day 1 (P<.001) and the lesion healed faster (P< 001) compared with placebo.
Conclusion: Doxycycline hyclate as a single application decreased pain and speeded recovery.
Pages: 147-150 | 700 Views 14 Downloads
How to cite this article:
Altaf H Chalkoo, Rizwan Hamid, Dr. Zahoor Bhat. Single application of topical doxycycline hyclate in the management of recurrent aphthous stomatitis. Int J Appl Dent Sci 2018;4(1):147-150.