Objectives: Evaluate the levels of MDA in serum and saliva of patients with OLP and to compare the levels.

Methods: The study included 30 cases of OLP patients which formed the study group and 30 cases of healthy individuals, which formed the controls.

Results: The levels of MDA were significantly higher in serum and saliva of cases with lichen planus than in normal.

Conclusion: Salivary and serum MDA were found to be higher in oral lichen planus patients which suggested that saliva can be used as an alternate and effective diagnostic tool in evaluating the oxidative stress status of an individual.