Objectives: In this review paper, we studied the Oral Leukoplakia (OLK) disease and its diagnosis and explored the application of Omics approaches in the study of OLK focussing mainly on understanding how omics approaches can lead to identification of novel biomarker molecules or molecular signatures with enough potential to be applied clinical practice.

Methods: “Omics” approaches [FTIR, GC-MS, LCMS, NMR] were applied for differentiating OLK from normal cases. Electronic databases (PubMed, Springer and Google Scholar) were searched for a detailed study of the researches.

Results: Analysis of the various diagnostic methods for OLK detection was studied and the early stage metabolomic profiling with the help of various “omics” approaches were explored.

Conclusions: It may be concluded that despite various advancements in OC therapy, few OC can show symptoms only at an advanced stage like in few OLK cases. Thus there arises a need of early detection of this potential neo plasticity by metabolomic profiling by biomarkers. Modern ‟Omics” strategies can potentially serve this need by giving major contribution to metabolomics profiling.