Introduction: The probiotics have the ability to modulate or influence the micro flora in a beneficial way leading to its increased use in various areas of healthcare. It provides a more natural and a non-invasive solution for management of commonly occurring oral diseases.

Aim & Objectives: To clinically evaluate and compare the efficacy of probiotic and chlorhexidine mouthrinses on plaque and gingival inflammation in children.

Materials and Method: The trial design was randomized parallel group study comprised of 60 healthy children of age group of 6-9 years. The subjects were assigned into three groups (A- control, B-chlorhexidine, C- probiotic). Plaque index and gingival index levels were recorded at baseline, 3rd day and 14th day.

Results: The Probiotic and chlorhexidine group had less plaque and gingival accumulation at the end of 14th day. There was significant difference in the plaque as well as gingival index between the chlorhexidine and probiotic group, probiotic group, being better than the chlorhexidine (mean value: 0.86±0.24 and 0.66±0.14) p<0.05 respectively.

Conclusion: Probiotic mouth rinse was found effective in reducing plaque accumulation as well as gingival inflammation. Hence, Probiotic mouth rinses have shown promising potential as an alternative effective and potentially safe anti-plaque agent in comparison to chlorhexidine.