Periapical inflammatory lesion is the local response of bone around the apex of tooth that develops after the necrosis of the pulp tissue or extensive periodontal disease. PRF is an excellent material for enhancing bone healing, owing to its stimulatory effect on angiogenesis and epithelialization because of local and continuous delivery of growth factors and proteins and thus can be used as graft material in bone defects.

Objective: To describe the use of PRF as a graft material for the treatment of periapical lesion.

Materials and Methods: Fifteen cases are presented in which conventional endodontic therapy failed to resolve the problem and periapical root-end surgery was required.

Results: At the end of six months, all patients showed significant bone regeneration.

Conclusion: It can be concluded that the use of platelet rich fibrin yields an ideal scaffold for use in tissue repair.