AUTHOR(S): Margarita Bermúdez-Pérez, Gloria Martínez-Sandoval, María Gabriela Chapa-Arizpe, Jesús Israel Rodríguez-Pulido and Marianela Garza-Enríquez

ABSTRACT:Autoimmune diseases affect 3 to 5% of the population, which the most common is rheumatoid arthritis (RA) in 27.6%. Many diseases including RA share pathogenic mechanisms and systemic cascades of inflammation, having an autoimmune disease significantly increases the risk of developing another disease. One of the risk factors for RA is periodontitis, porphyromonas gingivalis is a marker linked to determine the state of the disease. During inflammation takes place the citrullination of proteins and is produced under the action of the enzyme peptidyl arginine deiminase (PAD), this enzyme induces the citrullination of proteins and converts them into antigens recognized by certain specific antibodies to RA. PAD is expressed by inflammatory cells, and also by porphyromonas gingivalis, which is the only bacterium that expresses the PAD enzyme. In patients with RA the risk of periodontitis increases up to 13%. Some chronic and acute diseases are related to an aberrant expression of microRNA levels. To understand the disease caused by microRNA deregulation requires a specific expression in tissues that can recreate the individual function and mechanism of microRNA. They are critical regulators of host immunity and inflammatory response against pathogenic bacteria. The aim of this study is to conduct a literature review about the characteristics and risk factors of RA and the relation between periodontitis.

Pages: 333-336  |  1093 Views  70 Downloads