Materials and Methods: The study was carried out on 40 impacted lower third molars of 20 patients (8 males + 12 females) their ages ranged between (18-33 years).These patients had two symmetric impacted lower third molars. The samples were categorized into two groups, the normal saline was used as an irrigant solution in the first group and the (PVP-I) solution was used in the second group. The edema and pain were observed after one, two and seven days. The bleeding was estimated after 24 and 48 hours. After that the data was examined using SPSS statistic program. P values lower than 0.05 were considered statistically significant.

Results: There was a difference in the edema (P<0.05) between the two used solutions throughout the first and second day after surgical procedure. However, there was no significant difference in the edema between the two used solutions on day 7post-surgery. The bleeding and pain were at the same level between the two used solutions over all observations periods.

Conclusions: Povidone-iodine efficiency, which was used for surgical extractions of the lower third molars impacted on edema, was only noticed throughout the first few days followed surgical procedure. Its efficiency on bleeding was the same in comparison with normal serum used for the same purpose.

For this reason povidone-iodine was preferred to use for irrigation rather than the normal serum in case of surgical extractions of lower third impacted molars.