Vol. 5, Issue 4, Part E (2019)

Abstract: Class III malocclusion is believed to be a polygenic disorder that results from an interaction between susceptibility genes and environmental factors. Recent studies and advances in genetic sciences allowed the or-thodontists to better understand the effects of genetics on the etiology of Class III malocclusion. Knowing the relative impact of genetic and environmental factors would greatly enhance the clinician’s ability to treat malocclusions successfully. This article includes the cur¬rent data on the association between Class III malocclusion and genetics, as a review of the etiological factors of skeletal anomalies from the genetic point of view.