Methods: A case control study was conducted on 60 cases of OSMF and 60 controls. The serum vitamin A and vitamin E of all 120 participants were estimated by using spectrophotometer.

Results: The mean Vit A value in the patient group was calculated to be 24.30 μg/dl where as in the control group it was 30.36 μg/dl. Comparing the values between different stages, there was a gradual reduction in the Vit A levels as the stage advanced. The mean Vit E value in the patient group was 6.03 μg/dl which was marginally lower than the mean Vit E levels in the control group 9.03 μg/dl. Comparing the values between different stages, there were almost similar values of the Vit E levels across all the stages.

Interpretation & Conclusion: The serum levels of vitamin A and vitamin E between subjects with OSMF and the healthy controls did not show any significant difference when statistically evaluated. Nor was there any considerable difference across different stages of the disease.