Aim of study: This study aimed to evaluate the efficacy of pre-operative administration of single oral 200 mg lamotrigine in reducing the postoperative pain of impacted third molar surgery.

Materials and Method: In this randomized controlled trial, 80 adult patients were divided into two groups (n= 40) to receive either 200 mg oral lamotrigine for 1 hour before the removal of impacted third molar. The patients were monitored for 4 hours in the recovery room and pain intensity was measured through visual analogue scale (VAS) for the next 12 hours at 30-minute intervals. The time and number of rescue analgesics used in 12 hours was also recorded.

Results: Two groups were not statistically significantly different regarding the severity of postoperative pain. (p= 0.523)

Conclusion: Accordingly, pre-emptive administration of lamotrigine was not effective in diminishing the postoperative acute pain of impacted third molar extraction