International Journal of Applied Dental Sciences
2020, Vol. 6 Issue 3, Part H
Effectiveness of 1% curcumin gel subgingival application on interleukin-6 levels in chronic periodontitis patients
AUTHOR(S): Putri Lubis, Rini Nasution, Syafruddin Ilyas, Irma Ervina and Ameta Primasari
ABSTRACT:Chronic periodontitis is inflammation caused by bacterial plaque that can cause periodontal tissue damage and ultimately cause tooth loss. In periodontitis patients, the production of proinflammatory cytokines such as IL-6 increases, these cytokines can influence the progression of periodontitis. The periodontitis treatment is mechanical therapy which is coupled with the administration of antimicrobial and anti-inflammatory drugs. Curcumin has antimicrobial and anti-inflammatory effects by increasing the production of IL-6 induced by lipopolysaccharides. This study aims to analyze the effectiveness of 1% curcumin gel subgingival application on IL-6 levels reduction before and after scaling and root planning. This study is experimental with pre and posttest control group design and is divided into 3 groups from 21 patients with chronic periodontitis. Each group before scaling and root planing was examined for IL-6 levels in the gingival crevicular fluid and then applied 1% curcumin gel, 0.2% chlorhexidine gel, without gel application and re-examined on the 7th day. IL-6 levels were analyzed by ELISA method. The data obtained were processed statistically using the Wilcoxon Test and T test with a significant value of p<0.05. There was a statistically significant decrease in IL-6 levels. The difference of IL-6 levels in curcumin 1% gel group before scaling and root planing was 53.23 pg / mL and after scaling and root planing treatments were 40.00 pg / mL with the percentage reduction of IL-6 levels being 14, 96%. Subgingival application of curcumin 1% gel as an adjunct therapy of scaling and root planing treatments has proven to be effective in reducing levels of IL-6 in patients with chronic periodontitis.
Pages: 513-516 | 241 Views 14 Downloads
How to cite this article:
Putri Lubis, Rini Nasution, Syafruddin Ilyas, Irma Ervina, Ameta Primasari. Effectiveness of 1% curcumin gel subgingival application on interleukin-6 levels in chronic periodontitis patients. Int J Appl Dent Sci 2020;6(3):513-516.