Aim: To compare the post-operative pain after application of Silver Diamine Fluoride (SDF) 38% in cavitated primary molars, in relation to Interim Restorative Therapy (IRT).

Design: The study was performed on 20 carious primary molars in children aged 4-6 years attending the clinic in Pediatric Dentistry and Dental Public Health Department- Faculty of Dentistry -Cairo University. Partial excavation of caries on the walls of the cavity was performed then in group (A) SDF was applied in two visits with one-week interval, and finally Resin Modified Glass Ionomer Restoration (RMGI) was applied to the cavity. While, in group (B) Resin Modified Glass Ionomer restoration was applied immediately after partial caries excavation. Clinical and radiographic examinations were performed at three and six month’s follow-up periods for both groups.

Results: In both groups, 100% of patients had no complications at three and six months follow up periods; except for 10% of patients experienced failure of restoration at three months in group B. The results showed insignificant differences between groups regarding clinical and radiographic outcomes at both three and six months.

Conclusions: Silver Diamine Fluoride and Interim Restorative Therapy were clinically and radiographically successful when used in primary molars with cavitated dentin carious lesions.