Objective: To analyze the literature on the perforations that can occur during root canal treatment and the different bio ceramic materials used to seal them such as gray MTA, ProRoot MTA, Biodentine and Endo Sequence.

Methodology: Electronic bibliographic databases (PubMed, EBSCO, Cochrane) were used using the keywords perforations, bioceramics, MTA, ProRoot MTA, Biodentine, EndoSequence.

Results: MTA was the first bioceramic cement, providing good sealing, biocompatibility, and antimicrobial activity. However, it has been demonstrated that new bio ceramic cements have a better sealing capacity. ProRoot MTA is an excellent choice for sealing mainly furcated holes, a disadvantage is the change of color in the pieces. Biodentine, a biocompatible calcium silicate-based bio ceramic cement used in endodontic treatments, provides better sealing capabilities than other bio ceramic cements. Endosequence is a new bio ceramic cement, it can be found as a pre-mixed putty making it easier for the operator to handle, in addition, its sealing capacity is better compared to other bio ceramic cements. Conclusion: According to the literature reviewed, Biodentine and EndoSequence are the best bio ceramic materials for sealing and repairing endodontic holes.