Introduction: Intrabony defects associated with periodontal pockets can be successfully treated with bone graft and Guided Tissue Regeneration membrane (GTR). Demineralized freeze-dried bone allograft (DFDBA) consists primarily of collagen including bone growth and differentiation factors like Bone Morphogenetic Proteins. Perioglas® is a bioactive glass that is osteoconductive, composed entirely of elements naturally occurring in the body and bonds directly to the bone and soft tissue. Periocol® is a resorbable Guided Tissue Regenerative (GTR) membrane that delays the apical migration of gingival epithelium by excluding the gingival connective tissue and allows granulation tissue derived from PDL and osseous tissues to repopulate the space adjacent to the denuded root surface.

Objective: To compare DFDBA with Periocol® and Perioglas® with Periocol® membrane in the treatment of intrabony defects clinically and radiographically.

Methodology: A patient with bilateral intrabony defects was selected. In one site - Open Flap Debridement (OFD) with Perioglas® and Periocol® membrane was placed and on the other site – OFD with DFDBA and Periocol® membrane was placed.

Conclusion: DFDBA with Periocol® membrane has shown better results than Perioglas® with Periocol® membrane.