Materials and Method: In total, 20 freshly extracted human single-rooted maxillary premolars were used. Specimens instrumented with the Protaper gold rotary instruments were assigned randomly into two groups. In each group, root canals were filled with single-cone gutta-percha and one of the tested sealers. Each specimen was then scanned using. CBCT at a voxel resolution of 100 mm. Proportions of sections with voids in cross-sectional images and void volumes for each sealer were calculated in the apical, middle, and coronal thirds. Differences according to root canal sealers were evaluated statistically using the Kruskal–Wallis test and the Mann– Whitney U-test at a significance level of 5%.

Results: The analysis showed a decrease in void formation in the apical third, with a significant difference between the apical and coronal thirds among bioceramic sealers The bioceramic sealers (EndoSequence BC Sealer, Bio Root RCS) produced similar voids which had the fewest in the apical third of root canals among the sealers tested which can be related due to root canal anatomy variations