Objective: To analyze the literature on autologous platelet concentrates in regenerative endodontics, such as: Platelet Rich Plasma, Platelet Rich Fibrin, PRP/PRF Vs Blood Clot as a scaffold in regenerative endodontics.

Methodology: Using the keywords Regenerative Endodontic Treatment, Autologous Platelet Concentrates, Immature Teeth, Platelet-rich Fibrin, Platelet-rich Plasma, Revitalization Endodontics, the MEDLINE/PubMed and ScienceDirect databases were searched, with emphasis on the last 5 years. It was evaluated with the PRISMA and AMSTAR-2 guidelines.

Results: Platelet-rich plasma releases growth factors during the first hours after placement and induction of mesenchymal stem cells. Platelet Rich Fibrin is a second-generation platelet concentrate that releases growth factors more slowly, forming a network that traps leukocytes and platelets, liquid platelet rich fibrin has a higher concentration of leukocytes, which enhances immune defense in LPS-induced inflammation. Compared to blood clot, PRP and PRF show improved healing results, reducing infection and inflammation.

Conclusion: The use of autologous platelet concentrates presents a more controlled scaffold in regenerative endodontics, with successful results, such as periapical healing, root thickening and apical closure.