Vol. 8, Issue 1, Part D (2022)

Background: Oral submucous fibrosis (OSF) is one such potentially malignant condition that subjects the oral cavity to a widespread alteration in morphology and physiology. The present study was conducted to assess clinical and histopathological aspects of patients with oral submucous fibrosis in the background of oral squamous cell carcinoma.

Materials & Methods: 46 patients diagnosed with OSMF of both genders were included. Demographic and clinical information were recorded. Patients were divided into 2 groups of 23 each. Group I had both OSMF and OSCC and group II had OSCC. Haematoxylin and eosin-stained sections of the OSCC specimens were obtained for histopathological analysis.

Results: Primary site was lip in 2 and 1, tongue in 4 and 2, buccal mucosa in 12 and 10, FOM in 2 and 5, palate in 1 and 1, alveolar ridge in 2 and 4. Habits were betel quid in 8 and 3, smoking in 3 and 5, alcohol in 1 and 3 and all in 11 and 12 and lymph node metastasis was seen in 4 and 7 I group I and II respectively. The difference was significant (P< 0.05). Early fibrosis had early invasive in 2 and 5, well DSCC in 3 and 14, MDSCC in 2 each and PDSCC in 2 each in group I and II respectively. Intermediate fibrosis had early invasive in 2, Well DSCC in 3, MDSCC in 4 and PDSCC in 1 and advanced fibrosis in early in 2, well DSCC in 1 and MDSCC I 1 in group I. The difference was significant (P< 0.05).

Conclusion: High degree of prevalence of OSMF was observed among the OSCC patients. A non- significant association was observed in the degree of fibrosis with malignant transformation or the level of histopathological differentiation of the tumor.