Vol. 8, Issue 1, Part H (2022)

Abstract: Interleukin-6 (IL-6) is a proinflammatory cytokine that is produced locally in inflamed tissues after the activation of lipopolysaccharides and other cytokines such as in patients with periodontitis. Mangosteen peel extract gel application as a form of local application therapy contributed to the reduction of IL-6 and clinical parameters in stage III grade B periodontitis patients. This study aimed to analyze the effect of 4% mangosteen peel extract gel as additional scaling and root planing therapy on IL-6 levels in patients with stage III grade B periodontitis. This study was a pre and posttest control group design study with the number of samples divided into 2 groups. This study used 4% mangosteen peel extract gel which was administered locally into the subgingival after scaling and root planing and placebo gel was used as a comparison. Gingival crevicular fluid was taken before and after treatment in each group and IL-6 levels were measured using the ELISA kit Bioassay. The mean decrease in IL-6 levels before and after subgingival aplication of 4% mangosteen peel extract gel was significant (p< 0.05) i.e. (48.91±19.89) compared to the placebo control group (8.83±12.17). There was a significant difference (p< 0.05) in the decrease in clinical parameters in the test group compared to the control group.