AUTHOR(S): Zisis Vasileios, Zisis Stefanos, Dr. Dimitrios Andreadis and Dr. Poulopoulos Athanasios

ABSTRACT:Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and a main causal factor of dementia.
Objective: The aim of this article is to illustrate the intra correlations among periodontal diseases, dementia and Alzheimer disease, tooth loss and the underlying inflammation which is the link among different phenomena. Methods: We provide a thorough review of the literature.
Results: Periodontitis plays a key role in the initiation of systemic peripheral inflammation which may lead to neuroinflammation in the brain. Neuroinflammation is a necessary prerequisite for the development of Alzheimer. The reported tooth loss due to periodontal disease further worsens the clinical situation and the quality of life of the patient both directly, through improper food intake, and indirectly through the dysfunction of the masticatory system.
Conclusion: Periodontitis may be prevented in advance, the periodontal peripheral inflammation may be avoided, thus avoiding the subsequent neuroinflammation. Despite the indications so far, a clear and well-established connection between periodontitis and AD has yet to be proved.

DOI: https://doi.org/10.22271/oral.2022.v8.i1f.1455

Pages: 393-399  |  581 Views  102 Downloads