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International Journal of Applied Dental Sciences
  • Printed Journal
  • Indexed Journal
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P-ISSN: 2394-7489, E-ISSN: 2394-7497
ICV 2019: 92.11

2022, Vol. 8 Issue 1, Part F

Neuroinflammation: The link between periodontal disease and Alzheimer’s disease

AUTHOR(S): Zisis Vasileios, Zisis Stefanos, Dr. Dimitrios Andreadis and Dr. Poulopoulos Athanasios
ABSTRACT:Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and a main causal factor of dementia.
Objective: The aim of this article is to illustrate the intra correlations among periodontal diseases, dementia and Alzheimer disease, tooth loss and the underlying inflammation which is the link among different phenomena. Methods: We provide a thorough review of the literature.
Results: Periodontitis plays a key role in the initiation of systemic peripheral inflammation which may lead to neuroinflammation in the brain. Neuroinflammation is a necessary prerequisite for the development of Alzheimer. The reported tooth loss due to periodontal disease further worsens the clinical situation and the quality of life of the patient both directly, through improper food intake, and indirectly through the dysfunction of the masticatory system.
Conclusion: Periodontitis may be prevented in advance, the periodontal peripheral inflammation may be avoided, thus avoiding the subsequent neuroinflammation. Despite the indications so far, a clear and well-established connection between periodontitis and AD has yet to be proved.
Pages: 393-399  |  651 Views  140 Downloads


International Journal of Applied Dental Sciences
How to cite this article:
Zisis Vasileios, Zisis Stefanos, Dr. Dimitrios Andreadis, Dr. Poulopoulos Athanasios. Neuroinflammation: The link between periodontal disease and Alzheimer’s disease. Int J Appl Dent Sci 2022;8(1):393-399. DOI: https://doi.org/10.22271/oral.2022.v8.i1f.1455
International Journal of Applied Dental Sciences

International Journal of Applied Dental Sciences

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International Journal of Applied Dental Sciences