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International Journal of Applied Dental Sciences
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ISSN Print: 2394-7489, ISSN Online: 2394-7497
ICV 2019: 92.11

International Journal of Applied Dental Sciences

2022, Vol. 8 Issue 1, Part H

The effect of 4% mangosteen peel extract gel on interleukin-6 (il-6) levels and clinical parameters in stage iii grade b periodontitis patients

AUTHOR(S): Maulidatul Husna, Rini Nasution, Syafruddin Ilyas, Pitu Wulandari and Armia Syahputra
ABSTRACT:Interleukin-6 (IL-6) is a proinflammatory cytokine that is produced locally in inflamed tissues after the activation of lipopolysaccharides and other cytokines such as in patients with periodontitis. Mangosteen peel extract gel application as a form of local application therapy contributed to the reduction of IL-6 and clinical parameters in stage III grade B periodontitis patients. This study aimed to analyze the effect of 4% mangosteen peel extract gel as additional scaling and root planing therapy on IL-6 levels in patients with stage III grade B periodontitis. This study was a pre and posttest control group design study with the number of samples divided into 2 groups. This study used 4% mangosteen peel extract gel which was administered locally into the subgingival after scaling and root planing and placebo gel was used as a comparison. Gingival crevicular fluid was taken before and after treatment in each group and IL-6 levels were measured using the ELISA kit Bioassay. The mean decrease in IL-6 levels before and after subgingival aplication of 4% mangosteen peel extract gel was significant (p< 0.05) i.e. (48.91±19.89) compared to the placebo control group (8.83±12.17). There was a significant difference (p< 0.05) in the decrease in clinical parameters in the test group compared to the control group.
Pages: 531-534  |  46 Views  2 Downloads
How to cite this article:
Maulidatul Husna, Rini Nasution, Syafruddin Ilyas, Pitu Wulandari, Armia Syahputra. The effect of 4% mangosteen peel extract gel on interleukin-6 (il-6) levels and clinical parameters in stage iii grade b periodontitis patients. Int J Appl Dent Sci 2022;8(1):531-534. DOI: https://doi.org/10.22271/oral.2022.v8.i1h.1473
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International Journal of Applied Dental Sciences