Introduction: Of the malignant tumors of the oral cavity, 90% of them are oral squamous cell carcinomas, with a predilection to develop in the tongue and floor of the mouth being the most common sites. It is a lethal and disfiguring disease with an increase in its incidence, especially in the young population.

Case Report: We present the case of 2 patients of different gender, who attended a check-up due to the presence of a lesion on the right lateral edge of the tongue, with a time of 1 and 6 months of evolution; with different risk factors. When performing the inspection for the neck area, adenopathies were palpated in both patients. Incisional biopsies were performed for histopathological study through which the diagnosis of squamous cell carcinoma (OSCC) was obtained.

Conclusion: The timely detection of oral cancer and premalignant lesions is a vital issue for the patient's prognosis. Due to the high incidence of OSCC, the dental community is invited to detect, manage, refer and/or diagnose this pathology, for the benefit of the patient.