Objective: Analyze the literature of white spot lesions in pediatric dentistry, know the etiology, epidemiology, prevention, as well as the recommended treatment.

Methodology: To carry out this literature review, an electronic search was necessary using PubMed and Google Scholar with the words white spot lesions, etiology, epidemiology, prevention, treatment.

Results: WSL appear mainly as a result of inadequate oral hygiene, in addition, different associated factors were found such as the use of orthodontic appliances. Fluoride is a widely used agent for preventing incipient caries or white spot lesions, the first treatment option is remineralization with various remineralizing agents such as fluoride and Amorphous calcium peptide-phosphate casein-phosphate paste.

Conclusion: Among the prevention strategies for WSL, we can mention the education of parents, to carry out correct oral hygiene, as well as to educate on the correct nutrition and the use of preventive agents such as fluoride.