Objective: To analyze the use of antibiotic pastes, stem cells, scaffolds and growth factors in regenerative endodontic procedures.

Methodology: PubMed, Google Scholar, SCOPUS databases were reviwed with the following keywords "Stem cells, growth factors, antibiotic paste, scaffolds".

Results: The use of antibiotic pastes based on metronidazole, minocycline and ciprofloxacin provide a suitable medium for regeneration. Factors secreted by mesenchymal stem cells can be found in the cell culture medium, called conditioned medium. Concentrated growth factor has been found to promote proliferation, migration and differentiation of SCAPs. Tissues are organized as three-dimensional structures and appropriate scaffolding is necessary to provide a spatially correct position of cell location and regulate differentiation, proliferation or metabolism of stem cells.

Conclusion: Regenerative therapy is functional as long as the patient's internal clinical conditions as well as external factors are within the required parameters to evolve correctly. Currently, biomedicine has taken a very important path in dentistry for tissue regeneration.