Materials & Methods: 52 patients of RAS of both genders were divided into 2 groups. Group I comprised of patients with RAS and group II had age matched healthy control. 2 mL of unstimulated whole saliva was collected and salivary cortisol and DHEA levels were measured using ELISA kit.

Results: Group I had 20 males and 32 females and group II had 21 males and 31 females. 85% in group I and 26% in group II had salivary cortisol level >3 ng/ml and 15% in group I and 74% in group II had between 1.2–3 ng/mL. The difference was significant (P<0.05). DHEA levels 48–61 pg/ml was seen in 54% in Group I and 5% in Group II, <48 pg/ml was seen in 20% in group I and 94% in group II, >61 pg/ml was seen in 26% in group I and 1% in group II. The difference was significant (P<0.05).

Conclusion: The mean salivary cortisol and DHEA levels were elevated in the RAS patients compared to the healthy controls.