Home      Login     Signup
International Journal of Applied Dental Sciences
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
P-ISSN: 2394-7489, E-ISSN: 2394-7497
ICV 2019: 92.11

2022, Vol. 8 Issue 2, Part I

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

AUTHOR(S): Dr. I Girish Kumar, Dr. N Raghunath and Dr. Jyothikiran H
ABSTRACT:RANKL is a type II membrane protein bearing close homology to TNFSF members TRAIL, FasL, and TNF-a. RANKL has been definite for its key characteristic role in bone metabolism and the immune system. It is an apoptosis regulator gene, a binding partner of osteoprotegerin OPG, a ligand for the receptor RANK, and it controls cell proliferation by modifying protein levels. Osteoblasts and stromal stem cells receptor activator of NFκ-B ligand (RANKL), binds to receptor and RANK, is apparent on the surface of osteoclasts and their predecessors. Osteoprotegerin (OPG) secreted by osteoblasts and osteogenic stromal stem cells keep the skeleton from extreme bone resorption by binding to RANKL and averting it from interacting with RANK osteocytes. The critical cause of RANKL in alveolar bone remodelling during orthodontic tooth movement. The RANKL/OPG proportion in bone marrow is thus a significant element of bone mass in normal and disease conditions. This article reviews the role of the RANKL/RANK/OPG system in bone and other tissues in Orthodontic tooth movement.
Pages: 630-635  |  1577 Views  932 Downloads


International Journal of Applied Dental Sciences
How to cite this article:
Dr. I Girish Kumar, Dr. N Raghunath, Dr. Jyothikiran H. RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics. Int J Appl Dent Sci 2022;8(2):630-635. DOI: https://doi.org/10.22271/oral.2022.v8.i2i.1568
International Journal of Applied Dental Sciences

International Journal of Applied Dental Sciences

Call for book chapter
International Journal of Applied Dental Sciences