Introduction: The removal of germs, especially fungi, from the intricate three-dimensional root canal system is a crucial aspect of endodontic treatment. Antimicrobial flora in the endodontic canal is treated with intracanal medications. There is prevalence of C.albicans in oral cavity. The aim of this study is to compare the antimicrobial efficiency of three different intracanal medicament against C. albicans.

Material and Methods: There were 75 teeth removed for orthodontic purposes were randomly assigned to one of three exploratory groups (n = 25), and the following intracanal medications were used: GA-Ca(OH)2, GB-Leder mix paste, and GC-silver nanoparticles (SNP). After loading the various intracanal medications, all groups were randomly separated into three uniform subgroups (n = 5), and they were subsequently incubated for varied lengths of time at a temperature and humidity of 37 °C and 100%, respectively. A 0.1 mL aliquot of the microbial suspension was respectively plated on SDB agar. The number of CFU was determined and reported for groups A, B, and C after the incubation periods of 24 hours, 7 days, and 14 days, respectively.

Results: There was a notable dissimilarity between the groups A, B, and C (p<0.01). Group C was associated with a decreased amount of CFU at all three different meantime.

Conclusion: SNP alone was significantly better in its antimicrobial efficacy against C. albicans over the period of 24 hours, 7 days, and 14 days.