Introduction: Pulp regeneration is a successful biological procedure to replace structures that may be damaged in the tooth, including the root and pulpodentinal complex.

Objective: To evaluate the literature on pulp regeneration and its implication within the biological principles of regeneration, as well as its repair and disinfection of the dentin-pulp complex, current methods in pulp regeneration and their limitations and future of regenerative therapy.

Methodology: In this study the search codes were: pulp regeneration in conjunction with endodontics, objective, treatment, methods. The search for articles was performed in PubMed, Google Scholar and Scopus databases.

Results: Pulp regeneration seeks to restore pulp function as well as regenerate the tissues surrounding the tooth, consider future complications that could bring this type of treatment will be given by the inability of the formation of osteocementoid tissue, the treatment for regeneration that has greater efficacy for the elimination of infection is irrigation with the help of EDTA followed by NaOCl, Mechanized debridement has also proven to be a crucial step in this treatment, one of the new methods is the use of stem cells since it has been observed that they help in the neurovascularization of the pulp, so a complete formation of the root is expected although there may be risks such as obliteration of the canal or dental ankylosis.

Conclusions: Pulp regeneration is a tool that nowadays grants a good success rate, so it has been implemented as a first option treatment in cases of some infection or trauma of the tooth with incomplete development.