Introduction: Ozone can interact with blood components to have a positive impact on tissue microcirculation, oxygen metabolism, cell energy, immunomodulatory properties, and antioxidant defense systems. In dental surgery, ozone may be useful to promote hemostasis, enhance local oxygen supply, and inhibit bacterial growth. Ozone has been suggested for usage in dentistry due to its healing, antibacterial, and disinfecting qualities.

Aim: To assess the influence of topical ozone administration on patient comfort after third molar surgery. Material and Methods: Two equal groups of the forty patients with lower impacted third molars who required surgical extraction were chosen at random. Patients in Group (I) had odontectomy for an impacted mandibular 3rd molar. Patients in Group (II) underwent odontectomy of the impacted mandibular 3rd molar, then ozone gel was injected into the socket. The follow-up visits were performed where the intensity of pain, the symptoms of trismus, swelling and radiographic bone density were evaluated.

Results: Group II showed statistical significant difference of pain compared to group I while both groups showed no statistical significant difference with regard to swelling and trismus and radiographic bone density.

Conclusion: After odontectomy of the mandibular third molar, ozone gel application therapy proved helpful for reducing postoperative discomfort and improving quality of life. Yet, in addition to bone density, it had no impact on either post-operative edema or trismus.