Boron plays a crucial role and is likely to be important element for human body. Boron is present in the human system, with the highest concentration in bones and teeth. In recent years, there has been increasing research interest in the use of boron in human biological systems, particularly in applications of boron compounds for oral health in dental field. Additionally, studies have demonstrated that boron plays important role in development of new methods for immersion of boron compounds in dental materials. Dental materials that incorporate boron have the potential to be next generation class of biomaterials. Despite extensive research on boron's biological effect, more knowledge is required to comprehend it mechanism of action in oral environment and dental materials in long term clinical effect. This review aims to provide an overview of recent developments in boron research in prosthetic dentistry and to explore the effect on available dental materials and potential applications in the future.