Endodontic management of open apex includes conventional treatment method using calcium hydroxide for apexification or use of mineral trioxide aggregate plug. Use of calcium hydroxide for long time causes weakening of dentinal structure which may lead tooth to fracture in later stage. Mineral trioxide aggregate is advantageous as compared to increased number of appointments with calcium hydroxide. Recently, modified concept of regeneration has been suggested as the treatment plan of open apex tooth. Effective disinfection of root canal is of utmost importance for the regeneration of pulp dentin complex. This article presents a case report with endodontic regeneration using platelet rich fibrin for revitalization of immature non vital tooth.