Antiseptic agents are used as an adjunctive tool in periodontal therapy, to prevent infection, better plaque removal, as well as preoperative cleaning of the surgical site, and postoperative use. Chlorhexidine is considered a good antiseptic agent, but it has several important adverse health effects if not used correctly by the patient. The objectives of this review are: a) To understand the different antiseptics that exist, b) To determine the adverse effects of chlorhexidine, c) To compare the effects of antiseptics in different studies.