Background: Amnion membranes, which originate in the placenta, are rich in stem cells, growth factors, and other proteins and hormones that speed up the body's natural processes for repairing injuries and replacing lost tissue. “It has been established that platelet-rich fibrin (PRF) stimulates bone repair and regeneration by releasing growth factors upon activation from the platelets and being retained inside the fibrin matrix, in addition to stimulating the mitogenic response in the periosteum during normal wound healing. Treatment of localized gingival recession issues was accomplished using a coronally advanced flap (CAF) with either a platelet-rich fibrin (PRF) membrane or a bioresorbable amniotic membrane (AM) in this early controlled, randomized clinical research with an 18-month follow-up.”

Materials and Procedures: Sixteen adults in good health were surgically treated for Miller Class I recession abnormalities using CAF in conjunction with either ablative microsurgery (AM) or photorefractive keratectomy (PRK). The plaque index, recession depth, All patients' keratinized gingiva and bleeding gums were evaluated 6 and 18 months after surgery. “The paired t-test, repeated measures analysis of variance, Bonferroni test, and unpaired t-test were used for comparing the two groups, while the other tests were used for analyzing the data within each group.”

Results: “At the 6-month and 18-month checkups, there was no discernible difference between the groups on any clinical measure. Comparing gingival recession from baseline to 6 months (P = 0.000) and from baseline to 18 months (P = 0.001) shows statistical significance.” the PRF and amnion groups both showed significant improvements. In contrast, the median value between 6 and 18 months did not reach statistical significance.

Conclusion: In this research, we found that CAF + PRF and CAF + AM both achieve clinically meaningful outcomes in terms of root coverage, with AM demonstrating a greater percentage of root coverage than PRF.