Introduction: Dental autotransplantation is an economical and viable alternative for the replacement of teeth with closed apex. The use of piezoelectric surgery is a beneficial tool and is considered a less invasive technique, ideal for autotransplantation of dental organs.

Objective: To analyze the literature on dental autotransplantation using 3D replicas of donor teeth, as well as the prognosis of treatment in teeth with immature apex and complete apex, the use of piezoelectric for the extraction of the donor tooth and the use of tissue regeneration in the transplanted teeth.

Methodology: A review was carried out in the databases Scopus, PubMed and Google Scholar with the keywords "tooth autotransplantation", "guided tooth autotransplantation", "mature donor teeth", "3D replica model", "platelet-rich fibrin".

Results: The use of a 3D guide helps to know the anatomy and achieves accurate repositioning of the donor tooth, taking care of adjacent structures, reducing surgical time and periodontal ligament damage, to achieve higher long-term survival rates. Transplanted teeth with immature apex have a survival rate of more than 97% and their postoperative recovery is more comfortable, less painful and more bone tissue is preserved. Tissue regeneration contributes to the reduction of postoperative pain, helps healing by reducing inflammation, which increases the success rate of the transplanted teeth, but does not prevent future complications.

Conclusion: Dental autotransplantation is a valuable treatment option achieving successful long-term results with multiple advantages.