Objective: Photo biomodulation therapy has proven benefits in various dental treatments. The current systematic review aims to explore the role of laser photo biomodulation in modulating post-operative pain followed by endodontic treatment.

Methods: In this systematic review, randomised controlled clinical trials on low-level laser therapy/ photo-biomodulation in endodontic therapy were analysed. Database search was performed in PubMed/ Medline, Web of Science, Scopus and Cochrane Library, followed by literature search in Google Scholar.

Results: A total of 16 studies were included as per the set criteria. The included studies utilised diode laser (808-970nm), Indium gallium aluminium and Nd: YAG laser. All the included studies evaluated post endodontic pain after root canal therapy, direct pulp capping, endodontic surgery. Majority of the included studies showed significant benefits of photobiomodulation in post-operative pain management in endodontic therapy.

Limitations: Heterogeneity of the laser parameters and lack of power calculations for sampling among the included studies precludes solid recommendation of use of photobiomodulation therapy for post-endodontic pain management.

Conclusion: Although photobiomodulation therapy has proven potential benefits being a possible adjunct in post- operative pain management in endodontic therapy, it requires robust standardized randomized control trials to confirm the results of the systematic review.