Objective: Analyze the literature to share the information that has been investigated of uses of Botulinum toxin. We will explain some of the uses that it has such as: help patients with bruxism, correction of gingival smile, aesthetic use in face and in patients with migraine.

Methodology: An electronic search was carried out through PubMed, SCOPUS, Google Scholar and Mendeley, using the terms: “Botulinum toxin”, “bruxism”, "lips”, “pain", "teeth”. We identified 241 results and used 44.

Results: The use of Botulinum toxin as a treatment in Orofacial area has become very popular nowadays for different purposes. Some applications in this region are: in patients with bruxism for the decrease of muscle strength removing pain; in the correction of gingival smile when controlling the power of the lip lifting muscles; in facial aesthetics by causing muscle semi paralysis dynamic wrinkles are reduced; and as a treatment in patients with migraine in muscle application inhibiting the release of pain-inducing substances. It is important to study the anatomy of the craniofacial region and to have experience and enough knowledge to do this treatment because a wrong technique may bring complications.

Discussion: Even when Botulinum toxin has many benefits, the diffusion of the treatment has brought a lot of patients that want it without even knowing the adverse effects that it can bring, and sometimes they are treated with non-prepared injectors. It is important to share the information about this topic and the importance of doing it with a well prepared professional.

Conclusion: Botulinum toxin is an excellent treatment if applied in the right way. It is essential that this treatment is carried out with a professional with extensive knowledge in the area.